Oxidative Stress and Diseases: Clinical Trials and Approaches

Due to the fact that oxidative stress may play important roles in human disease development, great many basic and experimental studies have been conducted to clarify the mechanisms that regulate the imbalance between prooxidant and antioxidant systems. Knowledge and understanding of these mechanisms have led to the development of clinical trials and approaches, which have resulted in successful diagnosis and therapies, as well as novel tools to characterize these clinical mechanisms and provide better care to patients. As to evidence-based clinical applications in humans, significant progress is expected in future medicine. Identifying oxidative stress markers in humans is important, as well as developing strong tools in health promotion and disease prevention for outpatient clinics, bedside monitoring, and home medical care. In recent years, emerging evidence suggests oxidative stress may play an important role in many skin diseases and skin aging, possibly including atopic dermatitis. The paper by H. Ji and X.-K. Li entitled " Oxidative Stress in Atopic Dermatitis " provides an overview of an update on scientific progress linking oxidative stress to AD and discusses future treatment strategies for better disease control and improved quality of life for atopic dermatitis patients. There have been intense interest and active researches in the area of dietary antioxidants to develop functional food products. The work by W. Huang et al. entitled " Effect of Blueberry Anthocyanins Malvidin and Glycosides on the Antioxidant Properties in Endothelial Cells " reports that blueberries are a good resource of anthocyanins, which can protect cells from oxidative deterioration, and used as a potential functional food to prevent diseases related to oxidative stress. Peritonitis, which is the inflammation of the peritoneal tissue, can cause systemic inflammatory response and sepsis. Etanercept is the competitive inhibitor of TNF-í µí»¼ which inhibits the binding of TNF-í µí»¼ to cell surface receptors and limits its biological activity. In the work by Y. Yildirim et al. entitled " Effect of Intraperitoneal Etanercept on Oxidative Stress in Rats with Peritonitis " the authors showed that the TNF-í µí»¼ inhibitor, etanercept, in addition to antibiotics given in the early treatment of peritonitis results in more significant improvement of histopathological and oxidative parameters as compared to antibiotics alone. The pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. In the work by F. Dilek et al. entitled " Oxidative Stress in Children with Chronic Spontaneous …